Date of Completion
Akiko Nishiyama; Dennis Wright; Daniel Schwartz
University Scholar Major
Cellular and Molecular Physiology | Medicinal Chemistry and Pharmaceutics | Molecular and Cellular Neuroscience | Nervous System Diseases
Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments.
Sakya, Sagune, "Exploring the Effect of Novel Small Molecules on Oligodendrocyte Precursor Proliferation" (2016). University Scholar Projects. 27.