Medicine and Health Sciences
Females experience poorer recovery after ischemic stroke compared to males, even after controlling for age and stroke severity. IL-10 is an anti-inflammatory cytokine produced by T regulatory cells and Th2 CD4+ helper T cells. In ischemic stroke, an excessive IL-10 response contributes to post-stroke immunosuppression, which worsens outcomes. However, it is unknown if sex differences exist in IL-10 levels after ischemic stroke. In this study, we found that higher levels of IL-10 were associated with poor acute and long-term outcomes after ischemic stroke in female patients but not in males. After controlling for confounders, IL-10 was not an independent predictor of functional outcomes. This suggests that higher serum IL-10 levels may reflect factors that interact with sex such as age and stroke severity.
Conway, Sarah E.; O’Reilly, Meaghan Roy; Friedler, Brett; Staff, Ilene; Fortunato, Gilbert; and McCullough, Louise D., "Sex Differences and the Role of IL-10 in Ischemic Stroke Recovery." (2015). UCHC Articles - Research. 287.