Document Type



Life Sciences | Medicine and Health Sciences


Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several scales, ranging from the subcellular to the organismal. This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in iron metabolism and their underlying causes


Adv Exp Med Biol. Author manuscript; available in PMC 2015 Jun 13. Published in final edited form as: Adv Exp Med Biol. 2014; 844: 201–225. doi: 10.1007/978-1-4939-2095-2_10 PMCID: PMC4464783 NIHMSID: NIHMS695501