Document Type
Article
Disciplines
Life Sciences | Molecular Biology | Structural Biology
Abstract
Using MRS imaging and singular value decomposition (SVD), Manganas et al. (Science 318, 980,2007) reported a nuclear magnetic resonance diagnostic for neural progenitor cells. Characteristics of MRS experiments are known to be problematic for SVD-based methods. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, little significance can be attached to their result.
Recommended Citation
Hoch, Jeffrey C.; Maciejewski, Mark W.; and Gryk, Michael R., "Detection of Biomarkers by MRS Requires Error Analysis" (2008). UCHC Articles - Research. 12.
https://digitalcommons.lib.uconn.edu/uchcres_articles/12
Comments
Published in final edited form as:
Science. 2008 August 1; 321(5889): 640. doi:10.1126/science.1153058.