Life Sciences | Molecular Biology | Structural Biology
Using MRS imaging and singular value decomposition (SVD), Manganas et al. (Science 318, 980,2007) reported a nuclear magnetic resonance diagnostic for neural progenitor cells. Characteristics of MRS experiments are known to be problematic for SVD-based methods. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, little significance can be attached to their result.
Hoch, Jeffrey C.; Maciejewski, Mark W.; and Gryk, Michael R., "Detection of Biomarkers by MRS Requires Error Analysis" (2008). UCHC Articles - Research. 12.