Date of Completion
9-8-2014
Embargo Period
9-8-2014
Advisors
Steven Geary, Guillermo Risatti, John G. Neilan, Max Rasmussen
Field of Study
Pathobiology
Degree
Master of Science
Open Access
Open Access
Abstract
Foot-and-mouth disease virus (FMDV) gives rise to a highly contagious and economically important disease of cloven-hooved animals. Vaccination reduces the economic impact by inducing serotype-specific protection. Recently, a replication-defective adenovirus-vectored foot-and-mouth disease (FMD) subunit vaccine was developed and licensed. Serum virus neutralization (SVN) titer ≥1.5 to FMDV is the best predictor of vaccine-induced protection. However, protection does not always correlate with the presence of neutralizing antibodies. For example, some animals with high SVN titer develop signs of disease, and conversely, some animals with negligible SVN titer are protected. Categorizing cattle on the parameters of seroconversion and protection status yields four groups of cattle. Two of these groups are the expected outcome, protected with SVN titer ≥1.2 and unprotected with SVN titer
Recommended Citation
Zappulla, Frank, "Gene Expression Analysis of Bovine Peripheral Blood Mononuclear Cells in Response to Adenovirus-Vectored Foot-and-Mouth Disease Vaccine" (2014). Master's Theses. 672.
https://digitalcommons.lib.uconn.edu/gs_theses/672
Major Advisor
Lawrence Silbart