Identification of X-linked genomic imprinting in Mus musculus
Date of Completion
Over 80 mammalian imprinted genes have been discovered to date, and all of which reside on autosomes. Imprinted genes on the X chromosome in mammals was hypothesized not to occur due to dosage compensation, a process that silences one of the female's X chromosomes to adjust for equal expression between males and females. Behavioral analyses that involved girls with Turner syndrome, a condition in which girls only have one X chromosome, suggested that social behavioral disorders were dependent on which parental X chromosome is inherited. This finding supported the notion of a potential X-linked imprinted locus (loci) on the human X chromosome. Molecular analysis of mouse models for Turner syndrome produced the first identification of imprinted genes on a mammalian X chromosome. This discovery provided the first evidence that imprinted genes do exist on a mammalian X chromosome, and should initiate a search for X-linked imprinted genes on the human X chromosome.^
Raefski, Adam Stephen, "Identification of X-linked genomic imprinting in Mus musculus" (2006). Doctoral Dissertations. AAI3236143.