Date of Completion

6-20-2020

Embargo Period

9-16-2020

Keywords

Drug-Target Interaction, Singular Value Decomposition, Time Series Analysis, Motif Search, Jacobi SVD, Autoencoder, Ensemble Methods, Edit Distance

Major Advisor

Dr. Sanguthevar Rajasekaran

Associate Advisor

Dr. Reda Ammar

Associate Advisor

Dr. Ion Mandoiu

Field of Study

Computer Science and Engineering

Degree

Doctor of Philosophy

Open Access

Campus Access

Abstract

In this dissertation we propose novel approaches for data mining and machine learn- ing for some of the fundamental and advanced problems in the areas of data analysis and bioinformatics. A number of problems such as Drug-Target Interaction (DTI) pre- diction, Singular Value Decomposition (SVD), Time series Analysis (TSA) and motif search has been studied in this thesis. We have developed algorithms that outperformed the state of art in all of the above mentioned areas. We proposed algorithms for DTI prediction that outperformed all prior algorithms over benchmark datasets under mul- tiple scenarios. Our proposed approaches for Jacobi based SVD, both sequential and parallel, improves the computation time and work compared to the state of art. We also proposed ensemble based TSA models that improves classification accuracy sta- tistically significantly compared to all prior algorithm on benchmark dataset. We also introduced novel motif search algorithms for DNA and protein motifs.

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