Date of Completion
Spring 5-1-2020
Project Advisor(s)
Elaine Choung-Hee Lee; Beth Taylor; Paul Thompson; Theodore Rasmussen
University Scholar Major
Exercise Science
Disciplines
Biochemistry, Biophysics, and Structural Biology | Cell and Developmental Biology | Kinesiology | Medicine and Health Sciences | Physiology
Abstract
Statins are widely prescribed and used chronically, but we know little about the effects on long-term protein homeostasis during stress and aging. Our aim was to quantify the effect of statins on stress-induced protein damage. We administered atorvastatin in a dose-response curve in Caenorhabditis elegans under naïve control conditions and in conditions of hypertonic and heat stress known to induce muscle damage measurable as countable puncta in a polyglutamine aggregation model of damage. We observed that there is significant polyglutamine aggregation variability among worms at baseline and thus further study requires within experiment baseline controls, per worm. Our results are that statins exacerbate (p
Recommended Citation
Yu, Daniel, "Mechanisms of statin effects on muscle and neuronal proteostasis" (2020). University Scholar Projects. 60.
https://digitalcommons.lib.uconn.edu/usp_projects/60