Document Type
Article
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC50 values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.
Recommended Citation
Bajrami, Besnik; Krishnan, Sadagopan; and Rusling, James F., "Microsome Biocolloids for Rapid Drug Metabolism and Inhibition Assessment by LC-MS" (2008). UCHC Articles - Research. 169.
https://digitalcommons.lib.uconn.edu/uchcres_articles/169
COinS
Comments
Drug Metab Lett. Author manuscript; available in PMC 2012 October 17. Published in final edited form as: Drug Metab Lett. 2008 August; 2(3): 158–162. PMCID: PMC3473178 NIHMSID: NIHMS412752